Aciphex drug interactions. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Proton pump inhibitor (PPI) interactions with anticancer drugs. Sep 29, 2024 · I share the most clinically significant PPI drug interactions in practice and those that may show up on your board exam. It works by reducing the amount of acid produced in the stomach. Aciphex comes in a delayed release tablet and is usually taken once a day. What is Aciphex? Aciphex has active ingredients of rabeprazole sodium. Distribution of concomitant prescriptions at interaction risk with PPIs*, stratified by PPI and concomitant drugs. Jun 15, 2024 · Find patient medical information for Rabeprazole (AcipHex) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Aug 3, 2023 · What Drugs, Substances, or Supplements Interact with Aciphex? Aciphex may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, methotrexate, or cyclosporine. View details of known drug and lifestyle interactions Get insights on how drugs in your medicine chest can conflict with other medications Review and share Sep 30, 2012 · 1. A phase IV clinical study of FDA data: drug interactions are found among 218 people who take Pepcid ac (famotidine) and Aciphex (rabeprazole sodium). View drug interactions between Aciphex and dyphylline. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders. May 26, 2021 · What Do The Studies Say? There have been many, many studies looking into the potential interaction between Plavix and omeprazole (and PPI drugs in general). It may also be used together with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers associated with infections caused by the H. 1080/17425255. *Among medications potentially interacting with PPIs, we took into account those that were mostly prescribed and associated with major clinical relevance, as a consequence of drug-drug interactions. Do not chew, crush or split Aciphex tablets ACIPHEX Sprinkle is a proton-pump inhibitor (PPI) indicated for the treatment of Gastroesophageal Reflux Disease (GERD) in pediatric patients 1 to 11 years of age (1). Of the total drug interactions, 134 are major, 330 are moderate, and 26 are minor. Rabeprazole is a proton pump inhibitor (PPI) that A Major Drug Interaction exists between Aciphex and clopidogrel. These drugs, which are very expensive and usually well tolerated, have dramatically improved cancer prognosis. Ciprofloxacin Interactions There are 727 drugs known to interact with ciprofloxacin, along with 10 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 19 are major, 154 are moderate, and 18 are minor. With high dose Comprehensive disease interaction information for Aciphex. Pharmacology, adverse reactions, warnings, and ACIPHEXside effects. It works by reducing the amount of acid in the stomach. John’s wort is known to interact Dec 25, 2024 · AcipHex Sprinkle side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. CLINICAL EVIDENCES SUPPORT DRUG INTERACTION Recent studies of the influence of PPIs on clinical outcomes with clopidogrel therapy are summarized in Table 1. Gastric acid antisecretory drugs and particularly proton pump inhibitors (PPIs) revolutionized the treatment of gastroduodenal ulcers and severe Oct 19, 2025 · Key Takeaways Nexium is considered the most effective PPI for GERD, but it is more expensive than omeprazole. Compare Aciphex head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Proton pump inhibitors (PPIs) are widely prescribed for the treatment of gastric acid-related disorders and the eradication of Helicobacter pylori. Check Aciphex sprinkle in the real world. A phase IV clinical study of FDA data: drug interactions are found among 187 people who take Augmentin (amoxicillin; clavulanate potassium) and Aciphex (rabeprazole sodium). RABEPRAZOLE (ra BE pray zole) treats heartburn, stomach ulcers, reflux disease, or other conditions caused by too much stomach acid. Read more about the prescription drug RABEPRAZOLE DELAYED-RELEASE - ORAL. Feb 3, 2025 · Aciphex package insert / prescribing information for healthcare professionals. Aug 22, 2023 · Aciphex is used to treat gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. It is often used in gastroesophageal reflux disease. pylori) bacterial infections in the stomach. Talk with your healthcare provider about the options. S. Retail clinicians should have a careful plan to manage patients on PPIs and antacids, and patients should be monitored at every clinic visit to determine whether the medication should be continued. 2 days ago · Proton pump inhibitors (PPIs) are medications that slow acid production in your stomach to relieve issues like acid reflux, indigestion, ulcers, and more. . John’s Wort Effect: Possible Harmful Interactions The herb St. Apr 4, 2024 · Aciphex - General Information Aciphex is an antiulcer drug in the class of proton pump inhibitors. John’s wort, vitamin E, vitamin B 12 DRUGS IN THIS FAMILY: Lansoprazole (Prevacid), omeprazole (Prilosec) St. The normalization of platelet function by co-therapy with clopidogrel and PPI after platelet function is inhibited by clopidogrel mono-therapy indicates a pharmacologically relevant drug interaction. Feb 1, 2016 · Multiple drug interactions and adverse effects need to be considered when prescribing these medications (Table). ACIPHEX prescription and dosage information for physicians and health care professionals. g The need for long-term treatment of these disorders raises the potential for clinically significant drug interactions in patients receiving proton pump inhibitors and other medications. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e. In addition, they are routinely prescribed for the prevention of gastrointestinal bleeding in patients receiving a dual antiplatelet therapy consisting … Jun 10, 2025 · Overview of proton pump inhibitors, their uses, and potential adverse effects in managing acid-related disorders. 2022. Nov 4, 2020 · 7 DRUG INTERACTIONS Table 2 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with ACIPHEX delayed-release tablets and instructions for 8 USE IN SPECIFIC POPULATIONS Proton pump inhibitors and statins: a possible interaction that favors low-density lipoprotein cholesterol reduction? Table 2 includes drugs with clinically important drug interactions when administered concomitantly with ACIPHEX delayed-release tablets and instructions for preventing or managing them. Jul 4, 2022 · Areas covered This review will discuss the latest updates on drug–drug interactions with PPIs, focusing on the last 10-year publications in the following areas: anti-infective agents, anticancer drugs, antiplatelet agents and anticoagulants, and antidiabetics. Risedronate Interactions There are 113 drugs known to interact with risedronate, along with 5 disease interactions, and 2 alcohol/food interactions. eHealthMe is studying from 37 Aciphex sprinkle users for the drug's side effects, drug interactions, effectiveness and more. A phase IV clinical study of FDA data: drug interactions are found among 342 people who take Carafate (sucralfate) and Aciphex (rabeprazole sodium). Clopidogrel/PPI drug interaction Although the concurrent administration of clopidogrel and PPIs is recommended by guidelines in various situations, a major concern of co-administration is the potential for a CYP450-mediated drug interaction. Of the total drug interactions, 27 are major, 195 are moderate, and 20 are minor. Rabeprazole is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. Aug 24, 2025 · Evidence-based interaction details between Rabeprazole Sodium (brand name (s): Aciphex, Aciphex Sprinkle) and Vitamin D, including interaction severity and how likely the interaction is to occur. A phase IV clinical study of FDA data: drug interactions are found among 379 people who take Claritin (loratadine) and Aciphex (rabeprazole sodium). What is Aciphex sprinkle? Aciphex sprinkle has active ingredients of rabeprazole sodium. PPIs can have interactions with certain drugs, so avoid drinking alcohol while taking them. Find medical information for Aciphex on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. The aim was to assess whether initiation of PPI treatment among users of warfarin leads to increased INR values. Table 2 includes drugs with clinically important drug interactions when administered concomitantly with ACIPHEX delayed-release tablets and instructions for preventing or managing them. ACIPHEX® (rabeprazole sodium) Delayed-Release Tablets, for oral use ACIPHEX® SprinkleTM (rabeprazole sodium) Delayed-Release Capsules, for oral use Initial U. Studies in healthy subjects have shown that Aciphex does not have clinically significant interactions with the drugs studied, including warfarin, phenytoin, theophylline or diazepam metabolized by the CYP450 system. Since proton pump inhibitors are widely used, we evaluated the supportive evidence for the probability of occurrence and potential seriousness of this drug interaction. Learn about side effects, dosages, drug interactions, and more. Aciphex, as is the case with other members of the PPI class of compounds, is metabolized through the cytochrome P-450 (CYP450) hepatic drug metabolizing system. Learn about side effects, interactions and indications. This table provides information on the known or predicted interactions between protease inhibitors and non-antiretroviral drugs. Aciphex prices starting at $1661. Based on drug interaction studies conducted with the components of Stribild, no clinically significant drug interactions have been either observed or are expected when coadministered with What drugs interact with Aciphex (rabeprazole)? Table 2 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with Aciphex delayed-release tablets and instructions for preventing or managing them. eHealthMe is studying from 25,299 Aciphex users for the drug's side effects, drug interactions, effectiveness and more. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. This attention reflects several factors, including the blockbuster status of the implicated drugs, a theoretically at-risk population in the tens of ACIPHEX prescription and dosage information for physicians and health care professionals. These medicines may also interact with certain foods or diseases. Nov 23, 2009 · With this background, the recently postulated drug interaction between proton pump inhibitors (PPIs) and clopidogrel is in a league of its own, spawning a flurry of research and editorializing in a relatively short time, and more is on the way. Includes: indications, dosage, adverse reactions and pharmacology. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; sudden pain or trouble moving your hip, wrist, or back; seizure (convulsions A phase IV clinical study of FDA data: drug interactions are found among 101 people who take Linzess (linaclotide) and Aciphex (rabeprazole sodium). PPIs are available as over-the-counter (OTC) and prescription drugs. Jan 24, 2025 · Detailed dosage guidelines and administration information for Aciphex (rabeprazole sodium). Tell your doctor all medications and supplements you use. May 22, 2023 · Avoid the combined use of clopidogrel with omeprazole or esomeprazole due to a significant interaction. A Major Drug Interaction exists between Aciphex and Plavix. View drug interactions between Aciphex and azithromycin. Jul 4, 2022 · An update on drug-drug interactions associated with proton pump inhibitors July 2022 Expert Opinion on Drug Metabolism & Toxicology 18 (5) DOI: 10. Pemetrexed and methotrexate are excreted by renal transporters (hOAT3) inhibited by PPIs, resulting in higher risk of hematological toxicity. Find drug information for Rabeprazole Sodium or Aciphex View drug interactions between Aciphex and gabapentin. Discover more about Aciphex, including its uses, side effects, dosage, images, and alternative medications. A Major Drug Interaction exists between Aciphex and dasatinib. ACIPHEX (rabeprazole sodium) tablet, delayed release What is Aciphex? Aciphex has active ingredients of rabeprazole sodium. A Minor Drug Interaction exists between Aciphex and Vitamin B12. Of the total drug interactions, 22 are major, 210 are moderate, and 5 are minor. Jun 4, 2024 · What are some common drug interactions with proton pump inhibitors? Discover how ClinicalKey AI answers this and other questions from clinicians about medical topics. T he development and introduction of the first proton pump inhibitor (PPI), omeprazole (Prilosec), for the management of acid-peptic disorders marks one of the great success stories in gastroenterology. Oct 1, 2025 · Description Rabeprazole is used to treat duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. Check Aciphex in the real world. Methods: The probability of occurrence was evaluated based on the clinical, pharmacokinetic and in vitro evidence using the Drug Interaction Probability Scale. Nov 10, 2010 · These highlights do not include all the information needed to use ACIPHEX safely and effectively. Most have shown that there is a clinically significant interaction, with a real world impact. The drug interaction with the greatest clinical importance is the reduction in benzodiazepine clearance by omeprazole. Brand Names Aciphex, Pariet Generic Name Rabeprazole DrugBank Accession Number DB01129 Background Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. Approval: 1999 Nov 23, 2009 · With this background, the recently postulated drug interaction between proton pump inhibitors (PPIs) and clopidogrel is in a league of its own, spawning a flurry of research and editorializing in a relatively short time, and more is on the way. Interaction with Methotrexate: Concomitant use with PPIs may elevate and/or prolong serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. Severe peptic strictures were once a highly Modulation of Gastric pH Group-specific interactions between PPIs and other drugs may result from a PPI-induced increase in gastric pH, which can decrease the soluble amount of other drug substances, alter drug release from products with pH-dependent dissolution properties, or indirectly impact bioavailability by changing the kinetics of pro-drugs. A phase IV clinical study of FDA data: drug interactions are found among 140 people who take Eliquis (apixaban) and Aciphex (rabeprazole sodium). Consumer information about the medication RABEPRAZOLE DELAYED-RELEASE - ORAL (Aciphex), includes side effects, drug interactions, recommended dosages, and storage information. ACIPHEX® (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. The incidence of clinically significant drug interactions increases proportionately with the number of drugs taken and with the age of the patient. A phase IV clinical study of FDA data: drug interactions are found among 6,993 people who take Aciphex (rabeprazole sodium) and Dexilant (dexlansoprazole). View detailed information regarding this drug interaction. Aug 6, 2016 · Table 2 includes drugs with clinically important drug interactions when administered concomitantly with ACIPHEX delayed-release tablets and instructions for preventing or managing them. May 1, 2023 · Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. View drug interactions between Aciphex and Riomet. Of the total drug interactions, 3 are major, and 110 are moderate. [1] Voquezna Interactions There are 242 drugs known to interact with Voquezna (vonoprazan), along with 2 disease interactions. 35, 36, 37 Inhibition of gastric H+K+ ATPase increases the gastric pH and reduces absorption of many anticancer drugs, particularly tyrosine kinase inhibitors (TKIs), capecitabine and cyclin Apr 17, 2023 · Compare proton pump inhibitors (PPIs), see list of brand and generic names, common uses for acid reflux and ulcers, user ratings, and safety info. INTERACTIONS: Folate, ginkgo biloba, kava, minerals, prescription medications, St. Feb 8, 2023 · New concepts and drugs have revolutionized medical treatment for cancers. See full prescribing information for ACIPHEX. Therefore, it is important to understand the mechanisms for drug interactions in this setting. However, this drug-drug interaction is sparsely investigated in a clinical setting. 86. Background and Rationale of Drug-Drug Interactions (DDIs) of Proton Pump Inhibitors (PPIs) Proton pump inhibitors (PPIs) are a group of substituted benzimidazole sulfoxide drugs with strong inhibitory effects on gastric acid secretion in the parietal cells of the stomach. Includes dose adjustments, warnings and precautions. Includes PPIs - C. Doxycycline Interactions There are 237 drugs known to interact with doxycycline, along with 3 disease interactions, and 2 alcohol/food interactions. However, given the extremely high number of people being treated with PPIs, clinicians should remain vigilant for interactions that may be clinically significant and req … View drug interactions between Aciphex and Pepcid. Jan 7, 2025 · Learn about AcipHex uses, dosage, side effects, food interactions, and more. Until the latter part of the 20th century, complications of acid-peptic disease were among the most common problems faced in gastroenterology. View drug interactions between Aciphex and Pepto-Bismol. Aciphex Sprinkle Interactions There are 191 drugs known to interact with Aciphex Sprinkle (rabeprazole), along with 4 disease interactions. Jul 9, 2024 · This cross-sectional study evaluates the consistency between summary of product characteristics and interaction checkers for potential drug-drug interactions with proton pump inhibitors (PPIs). A Major Drug Interaction exists between Aciphex and belumosudil. Brian Staiger discusses alternative options to help avoid a drug interaction between Plavix and PPI drugs. Apr 19, 2011 · Based on the lack of definitive data regarding a clinically relevant interaction between these drugs, it is not appropriate at this time to recommend termination of PPI coadministration (including omeprazole) in clopidogrel-treated patients or to suggest alternative therapeutic strategies. Jul 4, 2025 · Certain medications should not be taken with magnesium, including certain antibiotics, PPI drugs, diuretics, bisphosphonates, and high doses of zinc. Aciphex belongs to a group of drugs called proton-pump inhibitors (PPIs). Other PPIs are considered safe with clopidogrel. These articles are subsequently separated into two different categories depending upon that support or against the drug-drug interaction between clopidogrel and PPIs. However, concerns have arisen, potentially linking PPI use to kidney disease and cognitive decline, causing some patients to file lawsuits. Aciphex inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. Risk of potential drug-drug interaction with PPI described on SPC (•) or Drugdex Sep 7, 2023 · Learn about rabeprazole (Aciphex) usage and dosing. This attention reflects several factors, including the blockbuster status of the implicated drugs, a theoretically at-risk population in the tens of A phase IV clinical study of FDA data: drug interactions are found among 379 people who take Claritin (loratadine) and Aciphex (rabeprazole sodium). diff. Swallow Aciphex tablets whole. Sep 21, 2021 · Aciphex Sprinkle (rabeprazole sodium) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Although pharmacokinetic interactions of PPIs have been described with many drugs, their clinical relevance remains controversial. Camzyos Interactions There are 490 drugs known to interact with Camzyos (mavacamten), along with 3 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 179 are major, 453 are moderate, and 95 are minor. pylori bacteria. Get all the details about AcipHex from MedicinesFAQ. It belongs to a group of medications called PPIs. 2098107 Authors: Nov 8, 2013 · Aciphex is a prescription medication used to treat digestive problems such as heartburn and acid reflux. We must use them wisely for patients to fully benefit. AcipHex Sprinkle may cause serious side effects. Dec 21, 2022 · Home > Questions > Which Acid-Reducing Drugs Are Safe With Plavix? Which Acid-Reducing Drugs Are Safe With Plavix? In our latest question and answer, Dr. Proton pump inhibitors (drug interactions) DEFINITION: Drugs used to reduce levels of stomach acid. t0e6cik fbu6 bhl 3n keybt ctyb rr evo1d frp xumna